Insufficient standardization of a direct carbohydrate-deficient transferrin immunoassay.
نویسندگان
چکیده
Clin Med 1985;106:30–7. 2. College of American Pathologists 2006 participant survey for hemoglobin A electrophoresis. Northfield (IL): College of American Pathologists; 2006. 3. Hydragel 7 & 15 Hemoglobin(e) [package insert]. Norcross (GA): Sebia; 2006/09. 4. Helena procedural package inserts page. Helena Laboratories Website. Available at: http:// www.helena.com/Procedures/Pro015%20Rev6. pdf. Accessed March 28, 2008. 5. Paragon hemoglobin electrophoresis application guide EP-5 [package insert]. Fullerton (CA): Beckman Coulter.
منابع مشابه
Development and multicenter evaluation of the N latex CDT direct immunonephelometric assay for serum carbohydrate-deficient transferrin.
BACKGROUND Carbohydrate-deficient transferrin (CDT) is a promising biomarker of alcohol abuse. We describe the development and multicenter evaluation of N Latex CDT (Dade Behring), an automated, particle-enhanced, homogeneous immunonephelometric assay for directly determining CDT. METHODS N Latex CDT uses a monoclonal antibody that recognizes the structure of transferrin glycoforms lacking 1 ...
متن کاملMeasuring carbohydrate-deficient transferrin by direct immunoassay: factors affecting diagnostic sensitivity for excessive alcohol intake.
BACKGROUND carbohydrate-deficient transferrin (CDT) is a marker of alcohol intake that is used for detecting or monitoring alcohol-use disorders. The introduction of a new direct immunoassay for CDT justifies reevaluation of test performance and reexamination of factors affecting test diagnostic sensitivity and specificity. METHODS individuals enrolled in twin/family studies of alcohol use an...
متن کاملInterference of transferrin isoform types with carbohydrate-deficient transferrin quantification in the identification of alcohol abuse.
BACKGROUND Isoforms of transferrin interfere with measurement of carbohydrate-deficient transferrin (CDT) as a marker of heavy alcohol consumption. We evaluated the rate of inaccurate CDT results by immunoassays. METHODS We studied 2360 consecutive sera (1614 individuals) submitted for CDT assay without clinical information as well as samples from 1 patient with a congenital disorder of glyco...
متن کاملToward standardization of carbohydrate-deficient transferrin (CDT) measurements: II. Performance of a laboratory network running the HPLC candidate reference measurement procedure and evaluation of a candidate reference material.
Carbohydrate-deficient transferrin (CDT) is a descriptive term used for a temporary change in the transferrin glycosylation profile caused by alcohol, and used as a biomarker of chronic high alcohol consumption. The use of an array of methods for measurement of CDT in various absolute or relative amounts, and sometimes covering different transferrin glycoforms, has complicated the comparability...
متن کاملCarbohydrate-deficient transferrin measured by capillary zone electrophoresis and by turbidimetric immunoassay for identification of young heavy drinkers.
Carbohydrate-Deficient Transferrin Measured by Capillary Zone Electrophoresis and by Turbidimetric Immunoassay for Identification of Young Heavy Drinkers, Jean-Bernard Daeppen, Frederic Anex, Bernard Favrat, Alvine Bissery, Joelle Leutwyler, Roland Gammeter, Patrice Mangin, and Marc Augsburger ( Alcohol Treatment Center, CHUV, Lausanne, Switzerland; 2 Institute of Forensic Medicine, CHUV, Lausa...
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عنوان ژورنال:
- Clinical chemistry
دوره 54 6 شماره
صفحات -
تاریخ انتشار 2008